Inflammatory Mediators in Early Sepsis (Tusep)

University Hospital Tuebingen

Status: Unknown

Conditions: Inflammation

Study type: Observational

Funder types: Other

Identifiers

NCT02692118

AnaTubingen

Details and patient eligibility

About

Sepsis is still a challenge for clinicians since the detailed pathomechanism are still unknown and until now early markers for sepsis are not defined yet. Immunological pathways and new mediators defined in animal models are not yet investigated in patients with sepsis. Therefore the investigators will measure new mediators in patients with septic shock.

Full description

Semaphorins 1 to 7 will be determined in Blood of patients with early septic shock. Concentration will be compared with blood concentration of postoperative patients suffering systemic inflammatory response syndrome (SIRS).

Enrollment: 60 estimated patients

Sex: All

Ages: 18 to 85 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Septic Shock

Exclusion criteria

• Age < 18 > 85
• no consent of caregiver
• Trauma patients
• Burn patients
• Immunosuppression
• Pregnancy
• HIV- hepatitis infection

Trial design

60 participants in 1 patient group

sepsis

Description:

Patients with septic shock admitted to ICU