Inflammatory Mediators of Acute Kidney Injury in Intensive Care (PronMed)

Uppsala University

Status: Enrolling

Conditions: Acute Kidney Injury; Surgery; Sepsis

Study type: Observational

Funder types: Other

Identifiers

NCT03720860

2017-043PronMed

Details and patient eligibility

About

Acute kidney injury (AKI) affects more than 50% of patients admitted to the intensive care unit. The most common underlying cause is sepsis. Severe AKI in combination with sepsis is associated with high mortality. The mechanisms for sepsis-induced AKI are largely unknown. Our hypothesis is that the inflammatory response to an infection cause collateral damage to host tissue and contributes to the development of AKI. In this study we want to investigate the presence of novel inflammatory mediators in patients with sepsis, patients subjected to major surgery (sterile inflammation) and non-inflamed patients and correlate their levels with the risk for AKI.

Enrollment: 100 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

Patients admitted to the intensive/post operative care unit

• with septic shock or
• post major surgery or
• after intoxication with a chemical compund

Exclusion criteria

• Pregnancy or
• Breast feeding or
• Chronic kidney disease or
• intoxication with nephrotoxic compund or
• lack of informed consent

Trial design

100 participants in 3 patient groups

Sepsis

Description:

Patients admitted to the intensive care unit with sepsis

Surgery

Description:

Patinets subjected to major surgery and then admitted to the intensive care unit

Non-inflamed

Description:

Otherwise healthy patients admitted to the intensive care unit because of intoxication.