Inflammatory Profiling in Chronic Lung Disease

Ludwig Boltzmann Institute for Lung Vascular Research

Status: Enrolling

Conditions: Pulmonary Hypertension

Treatments: Other: Tissue sampling

Study type: Observational

Funder types: Other

Identifiers

NCT04654767

LBILVR-KLI 884-B

Details and patient eligibility

About

The aim of this study is to investigate the underlying inflammatory profile in patients with chronic lung disease and determine the association pulmonary hypertension.

Full description

Chronic lung diseases (CLD), such as chronic obstructive pulmonary disease (COPD) and idiopathic pulmonary fibrosis (IPF) are often complicated by the presence of pulmonary hypertension (PH), where even a mild elevation of blood pressure in the pulmonary arteries is associated with an even poorer prognosis. In this study, we will investigate whether similarities exist in the inflammatory profile that could potentially underlie all forms of pulmonary hypertension. Inflammatory data will be generated using flow cytometry, expression profiling and histological analysis and compared to the associated clinical data.

Enrollment: 60 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients undergoing lung transplant with COPD or IPF, with associated PH
• Signed informed consent

Exclusion criteria

• patients without written informed consent
• Signs of any infection such as pneumonia, pulmonary tuberculosis or infections with pleural effusions.

Trial design

60 participants in 3 patient groups

COPD-PH group

Description:

Patients with confirmed COPD and pulmonary hypertension

Treatment:

Other: Tissue sampling

IPF-PH

Description:

Patients with confirmed pulmonary fibrosis and pulmonary hypertension

Treatment:

Other: Tissue sampling

Control group

Description:

Control group without diagnosed COPD, IPF, or pulmonary hypertension

Treatment:

Other: Tissue sampling