Inflammatory Responses to Acute and Chronic Opioid Exposure in Humans

Stanford University

Status

Terminated

Conditions

Inflammation

Treatments

Drug: Morphine Sulfate

Study type

Interventional

Funder types

Other

Identifiers

NCT01749826

SU-10212009-4201

Details and patient eligibility

About

We aim to examine the extent to which inflammation is affected by acute and chronic opioid exposure.

Full description

We are interested in learning how the immune system and the inflammation process is effected by acute and chronic opioid exposure. Preliminary evidence in animal models show that acute opioid exposure leads to decreased inflammatory responses, while chronic opioid exposure causes increased inflammatory responses, as measured by local cytokine release at the site of injury. Translating these findings to humans will lead to important new mechanistic knowledge that may ultimately improve our ability to treat pain.

Enrollment

20 patients

Sex

All

Ages

18 to 60 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

18-60 years old
Healthy volunteer
Not allergic to remifentanil

Exclusion criteria

Patients younger than 18 or older than 70
Patients unwilling or unable to follow study instructions
Patients who don't speak English
Patients who are taking prescription opioid medications (e.g. vicodin, percocet) or are unwilling to refrain from taking anti-inflammatory medications such as Advil or Naproxen during 2 weeks prior to and during the 1 month study