Inflammatory Status of Visceral Adipose Tissue in Obese Patients Related to Periodontitis Severity (BACTERIOB)

Centre Hospitalier Universitaire de la Réunion

Status: Unknown

Conditions: Metabolism Disorders; Obesity; Parodontitis

Treatments: Other: SEVERE PERIODONTITIS; Other: NO PERIODONTITIS

Study type: Interventional

Funder types: Other

Identifiers

NCT02853734

2015/CHU/13

Details and patient eligibility

About

The research aims to compare the inflammatory status of visceral adipose tissue from obese patients depending on the presence and severity of periodontitis, in order to establish a potential causal link between the severity of the bacterial contamination and insulin resistance.

Full description

Recruitment of patients will be achieved in the department of digestive surgery. It will involve 122 patients with severe obesity undergoing bariatric surgery scheduled within the digestive surgery department. Patients recruited will be examined for evaluating the presence and severity of periodontitis, and separated into either group 1: for patients with moderate or severe periodontitis, and or group 2: for patients without or with mild periodontitis. The day before the surgery, blood sample will be collected for the analysis of circulating metabolic and inflammatory markers. Collection of stimulated saliva, periodontal sample and faeces samples (50 g) will also be carried out for bacteria determination. During the surgical procedure, a sample of visceral adipose tissue (50 g) will be collected and used for periodontal bacteria detection and inflammatory markers analyses.

Enrollment: 122 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patient eligible for bariatric surgery scheduled within the digestive surgery
• Patient affiliated to Social Security system or equivalent

Exclusion criteria

• Treatment with steroids or anti-inflammatory drugs in progress (or stopped for less than one month)
• Patients who received antibiotics within 3 months prior to the bariatric surgery for whatever duration
• Dental current (or older than 3 months)
• Participation in another research protocol

Trial design

Primary purpose: Diagnostic

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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122 participants in 2 patient groups

SEVERE PERIODONTITIS

Experimental group

Description:

Periodontal examination Biological samples collection: periodontal, saliva, blood, fecal, visceral adipose tissue

Treatment:

Other: SEVERE PERIODONTITIS

NO PERIODONTITIS

Other group

Description:

Periodontal examination Biological samples collection: periodontal, saliva, blood, fecal, visceral adipose tissue

Treatment:

Other: NO PERIODONTITIS