Inflammatory Targeted Laser Treatment of Knee Osteoarthritis

University of Bergen

Status: Completed

Conditions: Knee Osteoarthritis

Treatments: Other: LLLT; Other: Sham LLLT; Other: Exercise therapy

Study type: Interventional

Funder types: Other

Identifiers

NCT03750279

Bergen KOA laser RCT

Details and patient eligibility

About

This study is conducted to evaluate the effectiveness of low-level laser therapy (LLLT) as an adjunct to exercise therapy in knee osteoarthritis (KOA).

Enrollment: 50 patients

Sex: All

Ages: 50+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Any gender
• Age ≥ 50 years
• Pain on movement ≥ 40 mm Visual Analog Scale
• Knee pain for the last ≥ 3 months
• KOA verified with the American College of Rheumatology criteria using a history and physical examination, i.e. knee pain and at least three of the following: ≥ 50 years old, ≤ 30 minutes of morning stiffness, crepitus on active range of motion, bony tenderness, bony enlargement, and no palpable warmth of synovia

Exclusion criteria

• Knee alloplastic
• Total meniscectomy
• Intra-articular steroid injection and/or oral steroid treatment within the last six months
• Cancer
• Rheumatoid arthritis
• Severe cognitive deficit
• Neurological deficits affecting the knee
• Inability to speak and understand English/Norwegian

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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50 participants in 2 patient groups, including a placebo group

Exercise therapy + LLLT

Active Comparator group

Description:

* Exercise therapy 3 times per week for 8 weeks from baseline. * LLLT applied to the knee 3 times per week for 3 weeks from baseline.

Treatment:

Other: Exercise therapy

Other: LLLT

Exercise therapy + sham LLLT

Placebo Comparator group

Description:

* Exercise therapy 3 times per week for 8 weeks from baseline. * Sham LLLT applied to the knee 3 times per week for 3 weeks from baseline.

Treatment:

Other: Sham LLLT

Other: Exercise therapy