Influence and Relationships Between Square-stepping Exercise and Brain Activation, Cognitive Function, Physical Performance in Healthy Older Adults

National Yang Ming Chiao Tung University

Status: Completed

Conditions: Older Adults; Age Problem

Study type: Observational

Funder types: Other

Identifiers

NCT05891574

NYCU112078AE

Details and patient eligibility

About

Background and purposes: Square-stepping exercise (SSE) has been proved to be an effective intervention for motor and cognitive function in older adults. However, the underlying mechanism of SSE still remains undetermined. Therefore, the aim of this study is to elucidate the possible mechanism of SSE in healthy older adults.

Methods: This is a cross-sectional study. Inclusion criteria are: (1) age between 65 and 90 years, (2) no frailty indicated by Fried frailty criteria, (3) mini-mental state examination score≧24 and Montreal Cognitive Assessment score≧26, (4) ability to walk independently for 1 min. Brain activation differences between SSE patterns and usual walking, as well as relationships between brain activity, cognitive function, physical performance and SSE performance will be examined. This study will address both cognitive and motor aspects of possible mechanism in SSE. SPSS version 25.0 (SPSS Inc., Chicago, IL, USA) will be used to analyze the collected data in this study. One-way ANOVA with repeated measures is used to evaluate the differences in brain activation among usual walking, SSE-pattern 1, and SSE-pattern 2, with Bonferroni test for post hoc analysis. The Pearson correlation coefficient will be used to establish the relationships between brain activity and SSEs performance, between cognitive function and SSEs performance, and between motor function and SSEs performance. The significant level is set at p< .05.

Enrollment: 50 patients

Sex: All

Ages: 65 to 90 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Age between 65 and 90 years
• No frailty indicated by Fried frailty criteria
• Mini-mental state examination score equals to or more than 24, and Montreal Cognitive Assessment score equals to or more than 26
• Ability to walk independently for 1 min

Exclusion criteria

• Central nervous system disorders (such as stroke, Parkinson's disease, spinal cord injury)
• Any unstable physical condition, psychiatric disorder, and other neurological disorder, or diagnosed with learning disability which may affect participating this study

Trial design

50 participants in 1 patient group

healthy older adults

Description:

* Age between 65 and 90 years * No frailty indicated by Fried frailty criteria * Mini-mental state examination score equals to or more than 24, and Montreal Cognitive Assessment score equals to or more than 26 * Ability to walk independently for 1 min