Influence of a Prematuration Culture With a Phosphodiesterase-3 Inhibitor (PDE3-I) on Embryonic Aneuploidy Rate and Developmental Potential

Universitair Ziekenhuis Brussel

Status and phase: Terminated; Phase 1

Conditions: Infertility

Treatments: Procedure: prematuration culture

Study type: Interventional

Funder types: Other; Industry

Identifiers

NCT00823420

IWT-JSMDV2008

Details and patient eligibility

About

A single centre randomised controlled trial investigating the influence of a novel prematuration system (PMS) using a phosphodiesterase-3 inhibitor for in-vitro maturation of oocytes

Enrollment: 213 patients

Sex: Female

Ages: 18 to 35 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• healthy volunteers, either with PCOS/PCOS-like ovaries, or with normal ovaries, who undergo oocyte donation for research
• AFC at least 10
• AMH: > 5 μg/L
• Female age < 36 years

Exclusion criteria

• major uterine or ovarian abnormalities

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Single Group Assignment

Masking: None (Open label)

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213 participants in 1 patient group

in-vitro maturation of oocytes

Experimental group

Treatment:

Procedure: prematuration culture