Influence of a Single Dose Dexamethasone on the Time Course of Neuromuscular Blockade of Rocuronium

Kreiskrankenhaus Dormagen

Status: Completed

Conditions: Neuromuscular Block, Dexamethasone; Neuromuscular Block, Recovery

Study type: Observational

Funder types: Other

Identifiers

NCT01782820

dexarelax

Details and patient eligibility

About

The aim of the present study is to compare the time course of a neuromuscular block in patients receiving dexamethasone 8 mg in order to reduce postoperative nausea or vomiting several hours before surgery with patients receiving the drug immediately before induction of anaesthesia and patients without a dexamethasone prophylaxis. The primary end point is the time from start of injection of rocuronium until recovery to a train of four ratio (TOF ratio) of 0.9.

Enrollment: 108 patients

Sex: Female

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• patients aged 18 to 65 years,
• American Society of Anesthesiologists Physical Status I or II,
• 50-90 kg body weight,
• undergoing elective laparoscopic gynaecological surgery in general anaesthesia necessitating intraoperative neuromuscular blockade.

Exclusion criteria

• expected difficulties with endotracheal intubation (history of difficult intubation,
• reduced opening of the mouth (< 2cm), and Mallampati Score of 4),
• increased risk of pulmonary aspiration (gastrooesophageal reflux, full stomach, intestinal obstruction),
• known allergies to the drugs tested,
• pregnancy,
• neuromuscular disorders,
• intake of drugs affecting neuromuscular blockade, such as furosemide, magnesium or cephalosporins,
• hepatic-or renal insufficiency.

Trial design

108 participants in 3 patient groups

dexamethasone late

Description:

dexamethasone during induction of anesthesia

no dexamethasone

Description:

no dexamethasone during measurements

dexamethasone early

Description:

dexamethasone before induction of anesthesia