Influence of Adiponutrin in Chronic Liver Disease

Free University of Brussels (ULB)

Status: Completed

Conditions: Alcoholic Liver Disease

Study type: Observational

Funder types: Other

Identifiers

NCT01122797

ET-PNPLA3

Details and patient eligibility

About

Increasing evidence attests the influence of multiple metabolic genetic risk factors in the progression of alcoholic liver disease. Deleterious pathways involved in metabolism such as lipid peroxidation and cytokines have been implicated in promoting inflammation leading to fibrosis increase and liver injury progression. The aim of this study was to assess the role of rs738409 single nucleotide polymorphism in the PNPLA3 gene in alcoholic liver disease patients.

Enrollment: 658 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

ALD patients:

Inclusion Criteria:

• Excess alcohol intake
• Abnormal alanine aminotransferase (ALT) and aspartate aminotransferase (AST) or a suspicion of cirrhosis related to ALD
• Caucasian ethnicity

Exclusion Criteria:

• Presence of any other chronic liver disease
• Co-infection with human immunodeficiency virus

Controls:

Inclusion Criteria:

• Caucasian ethnicity

Exclusion Criteria:

• Presence of a disease

Trial design

658 participants in 2 patient groups

Alcoholic liver disease

Description:

Alcoholic liver disease patients undergoing a transjugular liver biopsy in our institution

Controls

Description:

Healthy controls patients recruited from the Occupational Medicine Department during a routine physical examination.