Influence of Anesthesia Methods on CTCs in TURBT Patients

Shanghai Jiao Tong University

Status: Not yet enrolling

Conditions: Bladder Cancer

Treatments: Procedure: Spinal Anesthesia; Procedure: General Anesthesia

Study type: Interventional

Funder types: Other

Identifiers

NCT05824299

CTC20230408

Details and patient eligibility

About

Multiple lines of evidence have shown that anesthesia method is associated with long-term outcomes in patients undergoing surgery due to cancers, including lung, breast, prostate, and bladder cancer, etc. Circulating tumor cells (CTCs) have been validated as prognostic biomarkers of a number of cancers. The aim of this study is to investigate the effects of anesthesia methods on the number of CTCs in patients receiving transurethral resection of bladder tumor (TURBT). The difference of anesthesia method is achieved by using general anesthesia in one group and spinal anesthesia in the other group.

Enrollment: 162 estimated patients

Sex: All

Ages: 18 to 85 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. .≤18 Age ≤85，ASAI-III.
2. .Patients with primary bladder cancer of Stage T1 to T4, who are scheduled for transurethral resection of bladder tumor.
3. .Written informed consent.

Exclusion criteria

1. History of surgery within 6 months.
2. Contraindications for spinal anesthesia.
3. With a history of any other malignancy.
4. Having received preoperative neoadjuvant therapy.
5. History of long-term opioid use.
6. Combined with autoimmune diseases or having a history of prolonged hormone use or immunosuppressant use within 1 year.
7. Combined with impaired liver function (Child - Pugh C) or renal insufficiency (serum creatinine level over 442μmol•L-1).
8. Known hypersensitivity or suspected allergy to intervention drugs.
9. Proposed postoperative admission to ICU.

Trial design

Primary purpose: Health Services Research

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

---

162 participants in 2 patient groups

General Anesthesia

Active Comparator group

Description:

Patients in this group will receive general anesthesia during TURBT.

Treatment:

Procedure: General Anesthesia

Spinal Anesthesia

Experimental group

Description:

Patients in this group will receive spinal anesthesia during TURBT.

Treatment:

Procedure: Spinal Anesthesia