Influence of Bag Volume Variation on the Reproducibility of Inert Gas Rebreathing

Universitätsmedizin Mannheim

Status: Completed

Conditions: Bronchial Asthma; Chronic Obstructive Pulmonary Disease; Restrictive Pulmonary Disease

Study type: Observational

Funder types: Other

Identifiers

NCT01762917

IGR_Vbag_MA

Details and patient eligibility

About

Non-invasive inert gas rebreathing (IGR) based on the Fick Principle showed promising results in the determination of pulmonary blood flow (PBF). The volume of the rebreathing bag (Vbag) is proposed by the system, however, elderly patients or those suffering from high grade pulmonary diseases might be unable to entirely rebreathe this volume and therefore fail to completely mix the test gases. The aim of our study is to evaluate the effect of adapting Vbag on the reproducibility of IGR measurements in patients with obstruction (group A), restriction (group B) and pulmonary healthy controls (group C).

Enrollment: 45 patients

Sex: All

Ages: 18 to 90 years old

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:

• ability to perform rebreathing maneuver

Exclusion Criteria:

Trial design

45 participants in 3 patient groups

Obstruction

Description:

Patients suffering from pulmonary obstruction

Restriction

Description:

Patients suffering from pulmonary restriction

Controls

Description:

Pulmonary healthy controls