Influence of Beer on Gut Microbiota and Biochemical Outcomes: Alcohol Impact.

Universidade do Porto

Status: Completed

Conditions: Healthy Volunteers

Treatments: Dietary Supplement: Non-alcoholic beer with 0.00 % alcohol; Dietary Supplement: Non-alcoholic beer with 0.45 % alcohol; Dietary Supplement: Beer with 5.20 % alcohol

Study type: Interventional

Funder types: Other

Identifiers

NCT03513432

MICROAL

Details and patient eligibility

About

Our aim is to assess the effects of moderate consumption of beer and non-alcoholic beer on gut microbiota and biochemical biomarkers in healthy adults.

Enrollment: 30 patients

Sex: Male

Ages: 18 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Adult men (18-65 years);
• Healthy volunteers free of chronic diseases with relevant effect on gastrointestinal system;
• Without a diagnosis of any digestive disease including functional bowel disorders such as IBS;
• Moderate alcohol consumers;
• Willing and able to provide written informed consent.

Exclusion criteria

• Documented cardiovascular disease (ischaemic heart disease - angina or recent or old myocardial infarction or previous or cerebral vascular accident, peripheral vascular disease);
• With diabetes or other relevant metabolic diseases;
• With any known infectious diseases, namely infections with HIV, Hepatitis B or C virus;
• Intake of antibiotics in the last 4 weeks and laxatives in the last 2 weeks;
• Subjects with history of drug, alcohol or other substances abuse.

Trial design

Primary purpose: Supportive Care

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

---

30 participants in 3 patient groups

Beer with 5.20 % alcohol

Experimental group

Description:

330 ml beer (5.20 % alcohol)/day

Treatment:

Dietary Supplement: Beer with 5.20 % alcohol

Non-alcoholic beer with 0.45 % alcohol

Experimental group

Description:

330 ml non-alcoholic beer (0.45 % alcohol)/day

Treatment:

Dietary Supplement: Non-alcoholic beer with 0.45 % alcohol

Non-alcoholic beer with 0.00 % alcohol

Experimental group

Description:

330 ml non-alcoholic beer (0.00 % alcohol)/day

Treatment:

Dietary Supplement: Non-alcoholic beer with 0.00 % alcohol