Influence of Brain Insulin Sensitivity on Peripheral Insulin Sensitivity

University Hospital Tuebingen

Status: Completed

Conditions: Insulin Sensitivity

Treatments: Drug: human insulin as nasal spray; Drug: Placebo

Study type: Interventional

Funder types: Other

Identifiers

NCT01847456

SFB 997 A01 WP7

Details and patient eligibility

About

The researchers will investigate if brain insulin action influences peripheral insulin sensitivity in healthy humans.

Enrollment: 10 patients

Sex: Male

Ages: 18 to 35 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• BMI < 28 kg/m2
• normal HbA1c
• healthy volunteers

Exclusion criteria

• Heparin induced thrombocytopenia (HIT)
• metal implants
• cardial diseases
• anemia
• patients taking any kind of drugs

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Single Blind

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10 participants in 2 patient groups, including a placebo group

insulin nasal spray

Experimental group

Description:

160 Units of human insulin as nasal spray

Treatment:

Drug: human insulin as nasal spray

Placebo nasal spray

Placebo Comparator group

Description:

Nasalspray containing placebo solution

Treatment:

Drug: Placebo