Influence of Breakfast Consumption on Chlorogenic Acid Metabolism in Humans

Nestlé

Status: Completed

Conditions: Healthy

Treatments: Other: Soluble Coffee

Study type: Interventional

Funder types: Industry

Identifiers

NCT01523028

11.12.NRC

Details and patient eligibility

About

Data and knowledge gathered on bioavailability of coffee phenolics is becoming more and more important, hence underlying the importance of better understanding the fate of these potential health promoting antioxidants. However, some analytical barriers as well as some key aspects of metabolism still remain to be fully elucidated to get the full picture of coffee metabolism and bioavailability. One aspect addressed in the present study is the impact of food matrix in modulating absorption, plasma appearance and urinary excretion of coffee bioactives.

Enrollment: 14 patients

Sex: All

Ages: 20 to 44 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy men and women
• Aged 20-44 years
• Caucasian origin
• Body mass index (BMI) 19-25 kg/m2
• Used to drinking coffee (similar to study coffee) on a daily basis
• Being able to tolerate a 48-hour coffee abstinence
• Normal oral glucose tolerance test
• Having signed the informed consent form

Exclusion criteria

• Taking medication or dietary supplements
• Smoking
• Performing a competitive sport
• Having metabolic disorders
• Long gut transit time (>24 h)
• Blood donor
• Irregularity in menstrual cycle (for women)
• Pregnancy (for women)
• Subject who cannot be expected to comply with the study procedures.
• Currently participating or having participated in another clinical trial during the last 4 weeks prior to the beginning of this study.

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: None (Open label)

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14 participants in 3 patient groups

Coffee, bread and honey

Experimental group

Description:

200 mL coffee + 2 bread rolls + honey

Treatment:

Other: Soluble Coffee

Coffee, bread and peanut butter

Experimental group

Description:

200 mL coffee + 1 bread roll + peanut butter

Treatment:

Other: Soluble Coffee

200 mL black coffee

Experimental group

Treatment:

Other: Soluble Coffee