Influence of Chronic Hypoxia on Oxidative Phenotype in Patients With Chronic Obstructive Pulmonary Disease (OXYPHEN)

Centre Hospitalier Universitaire de Saint Etienne

Status: Terminated

Conditions: Chronic Obstructive Pulmonary Disease

Treatments: Procedure: Muscle biopsy

Study type: Observational

Funder types: Other

Identifiers

NCT02532426

1108100

2011-A00856-35 (Other Identifier)

Details and patient eligibility

About

In addition to chronic airflow obstruction, patients with Chronic Obstructive Pulmonary Disease (COPD) suffer from skeletal muscle dysfunction which is a prominent and disabling feature and also an independent determinant of survival. Muscular impairment involves loss of muscle oxidative phenotype (OXPHEN: a slow-to-fast shift in fibre types and reduced oxidative capacity). Since hypoxia obviously is a key feature of COPD, the aim of this study is to elucidate the role of hypoxia in loss of muscle OXPHEN.

Thus, OXPHEN and expression levels of its key regulators will be determined in the baseline biopsies for association with the degree of hypoxemia. In addition, expression levels of the key OXPHEN regulators will be measured in pre/post exercise biopsies.

Enrollment: 13 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Diagnosis of COPD confirmed according to GOLD score.
• Hypoxemia group: resting arterial paO2 <55 mmHg.
• Normoxemia group : resting arterial paO2 > 67 mmHg

Exclusion criteria

• Unstable cardiorespiratory status (acute respiratory failure)
• Oxygen treatment started
• Inclusion in a pulmonary rehabilitation program in the last 6 months
• Anticoagulant treatment

Trial design

13 participants in 2 patient groups

COPD patients with chronic hypoxemia

Description:

COPD patients with chronic and severe arterial hypoxemia at rest (paO2\<55mmHg).

Treatment:

Procedure: Muscle biopsy

COPD patients with normoxia

Description:

COPD patients with normoxia at rest (paO2\>67mmHg), matched for age, sex, bronchial obstruction and lean mass.

Treatment:

Procedure: Muscle biopsy