Influence of Consecutive Strength- and Endurance Regimes on the Myonuclear Domain and Satellite Cell in the M. Vastus Lateralis of Old Healthy Men

University of Zurich (UZH)

Status: Completed

Conditions: Regeneration Potential of Healthy Old Men in Terms of Satellite Cell Activation

Treatments: Procedure: Training

Study type: Interventional

Funder types: Other

Identifiers

NCT01905345

REGPOT

Details and patient eligibility

About

Randomised training intervention.

Influence of consecutive training regime on the impact of the myonuclear domain and satellite cell

Sarcopenia

Despite that the muscle mass can be positively influenced by training, the loading with high weights and/or to the total exhaustion is for many old persons not possible.

Therefore we aim to enhance the myonuclei in the muscle fiber of old male subjects in a first phase by endurance training, in order to promote a more effective muscle growth in a second phase by resistance exercise.

Enrollment: 30 patients

Sex: Male

Ages: 18 to 75 years old

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

Inclusion criteria: -male

• no fever at the beginning and during the study
• between 60 years and 75 years
• non smokers
• no known cardiovascular and orthopaedic problems
• no cardiac pacemaker
• fulfilling the health criteria

Exclusion criteria: -female

• fever or cold at the beginning or during the study
• non MRI compatible metal implants
• under 60 years or over 75 years
• smoker
• cardiovascular or orthopaedic problems
• cardiac pacemaker
• not fulfilling the health criteria

Trial design

Primary purpose: Other

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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30 participants in 3 patient groups

Endurance and Resistance Training

Experimental group

Description:

Endurance and resistance exercise

Treatment:

Procedure: Training

Resistance Training

Experimental group

Description:

resistance exercise (12wk)

Treatment:

Procedure: Training

Resistance and resistance Training

Experimental group

Description:

resistance exercise (24 wk)

Treatment:

Procedure: Training