Influence of CPB and Mini CPB to the Absorption of the Metoprolol (Minimeto)

Kuopio University Hospital

Status: Unknown

Conditions: Drug Absorption

Treatments: Drug: blood concentration of metoprolol

Study type: Interventional

Funder types: Other

Identifiers

NCT01728272

KUH5101066

Details and patient eligibility

About

Influence of perfusion, miniperfusion and off pump coronary artery bypass grafting to the absorbtion of metoprolol postoperatively, hypothesis in that miniperfusion and off pump surgery does not decrease absorbtion of the metoprolol compared to conventional pefusion.

Full description

Influence of perfusion, miniperfusion and off pump coronary artery bypass grafting to the absorbtion of metoprolol postoperatively, hypothesis in that miniperfusion and off pump surgery does not decrease absorbtion of the metoprolol compared to conventional pefusion.

Blood samples for concentration of metoprolol are taken preoperaively, 1. and 3. day after operation, before and 10 times after intake of 50 mg metoprolol.

Sudy is randomized into 3 groups: 1. Miniperfusion n.15 2. Perfusion n.15 3. offpump n.15

Enrollment: 45 estimated patients

Sex: All

Ages: 18 to 75 years old

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria: elective CABG patient -

Exclusion Criteria: contraindication to metoprolol

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Single Group Assignment

Masking: Single Blind

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45 participants in 1 patient group

blood concentration of metoprolol

Experimental group

Description:

how does off-pump miniperfusion and perfusion CABG influence the absorption of metoprolol after CABG

Treatment:

Drug: blood concentration of metoprolol