Influence of Daily Activities on Retinal Microcirculation

Jiannan Huang

Status: Completed

Conditions: Retinal Microcirculation Disorder

Treatments: Behavioral: Beverage consumption; Behavioral: Body motion; Behavioral: Daily reading

Study type: Interventional

Funder types: Other

Identifiers

NCT03416088

YFZX2017001

Details and patient eligibility

About

The daily behaviors such as drinking coffee, wine, reading, exercise and body postural changes may have influence on the function or morphology of the retinal microcirculation in healthy people.A recent study found that the fingertips microvascular bed constricted obviously after the intake of a cup of coffee with caffeine, it significantly reduced blood flow to the fingers; Long reading of electronic products can induce significant dry eye symptoms, affect visual quality, and cause asthenopia. Microcirculation is critical for regulating vascular resistance and blood flow in organs. Fundus blood vessels is the only visible microvascular in vivo, its morphology and function changes not only associated with eye disease, but also with cardiovascular and cerebrovascular diseases. Optical coherence tomography angiography (OCTA) is a new technique which could acquire blood flow information in a non-invasive way without the use of dye. Magnetic resonance imaging (MRI) can quantitatively evaluation of cerebral blood flow and retina-choroid blood flow using the noninvasive arterial spin labeling technique in a large field of view (FOV) without depth limitations.The study tried to detect the influence of daily behaviors such as drinking coffee, red wine, reading , exercise, etc. on the retinal microcirculation with OCTA and MRI, and provide reference for health behaviors.

Enrollment: 54 patients

Sex: All

Ages: 18 to 35 years old

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria

1. Healthy adults
2. The age range was from 18 to 35 years old
3. Without another eye disease besides ametropia
4. The spherical equivalent is equal or above minus 3.00 diopters
5. No smoking or drinking
6. Average daily caffeine consumption no more than 1 cup of coffee
7. No diabetes, hypertension, heart disease, liver or kidney dysfunction
8. No medication taken recently

Exclusion Criteria

1. Mental disorders such as depression and anxiety
2. Intellectual disabilities
3. Female in menstruation, gestation period, perinatal period or lactation period
4. Unable to cooperate with eye examinations and test procedures
5. Heart disease, hypertension, diabetes, liver and kidney dysfunction and other chronic diseases
6. Patients with fever, acute infectious diseases
7. Other conditions that are not suitable for drinking alcohol or coffee, such as allergic to alcohol or coffee

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Single Blind

---

54 participants in 3 patient groups

Beverage consumption

Experimental group

Description:

Drink 300ml red wine (alcohol concentration:12.5%), 300ml coffee (caffeine concentration 72 mg), 300 ml Baijiu (Chinese liquor, alcohol concentration:12.5%) , SipSparkTM Probiotics (facilitates ethanol degradation) was taken 0.5 hour prior to Baijiu consumption, or 300ml water.

Treatment:

Behavioral: Beverage consumption

Daily reading

Experimental group

Description:

Reading paper books, playing video games with mobile phones, or non-reading.

Treatment:

Behavioral: Daily reading

Body motion

Experimental group

Description:

Exercise and body postural changes.

Treatment:

Behavioral: Body motion