Influence of Deep Versus Moderate Neuromuscular Blockade During General Anesthesia on 30-day Readmission Rates

Leiden University Medical Center (LUMC)

Status: Completed

Conditions: Postoperative Complications; Pneumonia; Postoperative Wound Infection

Treatments: Drug: deep neuromuscular block

Study type: Observational

Funder types: Other; Industry

Identifiers

NCT03174223

p17.031

Details and patient eligibility

About

Deep neuromuscular block (NMB) has shown to produce superior surgical conditions during various abdominal and non abdominal surgeries. It is however unknown if the application of deep NMB leads to favourable outcome, such as lower rate of postoperative complications in general and surgical infections in specific and ultimately lower readmission rates. In the leiden university medical center, deep NMB is routinely applied for a variety of procedures, most notably laparoscopic abdominal and retroperitoneal surgery, eye surgery and neuro radiologic intervention surgery, since 2014. This retrospective study intends to investigate whether the application of deep NMB for these procedures affects patient outcome and readmission rates.

Enrollment: 460 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• deep neuromuscular block
• moderate neuromuscular block
• general anesthesia
• complete anesthesia chart

Exclusion criteria

• incomplete anesthesia chart
• missing data regarding postoperative complications or readmission

Trial design

460 participants in 2 patient groups

Deep neuromuscular block

Description:

patients received a continuous rocuronium dose to maintain a depth of neuromuscular block of 1-2 twitches post tetanic count

Treatment:

Drug: deep neuromuscular block

moderate neuromuscular block

Description:

patients received neuromuscular block aimed at \> 0 twitches train of four