Influence of Edible Marijuana on Endurance Exercise Performance

Christopher Bell

Status and phase: Completed; Early Phase 1

Conditions: Endurance Exercise

Treatments: Drug: THC 5; Drug: Placebo

Study type: Interventional

Funder types: Other

Identifiers

NCT05192239

2827

Details and patient eligibility

About

Lots of people, including athletes and people who like to exercise regularly, enjoy marijuana. Some people believe marijuana might improve their ability to exercise. There are no recent, up-to-date scientific studies to suggest that this belief is right or wrong. The goal of this study is to determine the influence of marijuana on exercise performance.

Full description

The purpose of the proposed project is to provide athletes and the scientific community with data pertaining to the acute influence of edible marijuana on exercise performance, and the physiological responses to standardized exercise. Specifically, the investigators wish to determine: 1. The influence of edible marijuana on cardio-respiratory and metabolic responses to standardized cycle ergometer exercise. 2. The influence of edible marijuana on endurance exercise (time-trial) performance.

The investigators wish to determine if edible marijuana, ingested prior to exercise, is ergogenic (improves performance) or ergolytic (decreases performance).

The investigators hypothesize that edible marijuana will be ergolytic.

Enrollment: 17 patients

Sex: All

Ages: 21 to 40 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Between the age of 21 and 40.
• Weigh more than 110 pounds
• Habitual user of cannabis; average use of THC minimum of once per month during the previous year
• Prior use of cannabis product containing at least 10 mg of THC with no adverse reaction
• Habitual exerciser: exercised a minimum of 5 days per week, for a minimum of 30-minutes/session, during the previous year.

Exclusion criteria

• Identification of a contra-indication to exercise during a 12-lead exercise stress test.
• Pregnant or trying to become pregnant. Breastfeeding.
• Recipient of treatment for psychotic or bipolar disorder during the previous 2 years
• Recipient of treatment for Schizophrenia during the previous 2 years
• Planned surgery scheduled within 2-weeks of study participation

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Single Blind

---

17 participants in 2 patient groups, including a placebo group

Placebo

Placebo Comparator group

Description:

Delta-9-tetrahydrocannabinol (THC) free fruit snack gummy. One time, two gummies will be ingested prior to an exercise bout.

Treatment:

Drug: Placebo

10 mg THC

Active Comparator group

Description:

Delta-9-tetrahydrocannabinol (THC) 5 milligrams (mg) in gummy form. One time, two gummies will be ingested prior to an exercise bout.

Treatment:

Drug: THC 5