Influence of Emotions on Decision-making in Parkinson's Disease

Centre Hospitalier Universitaire de Saint Etienne

Status: Completed

Conditions: Parkinson Disease

Treatments: Other: cognitive examination; Other: Iowa Gambling Task; Other: viewing of video

Study type: Interventional

Funder types: Other

Identifiers

NCT03342339

2017-A02690-53 (Other Identifier)

1708168

Details and patient eligibility

About

Parkinson's disease mainly affects the dopaminergic neurons of the Substancia nigra, which project on the striatum. Neuronal death within this structure leads to a decrease in dopamine levels. Dopamine is a neurotransmitter essential to the proper functioning of the basal ganglia highly involved in the control of voluntary and involuntary movements.

It also leads to cognitive and behavioral changes. Among these changes, the investigators will mainly remember the idea of the emergence of difficulties to make the right decisions, for example at the financial, medical .... This disruption would be the result of executive dysfunction. By definition, executive functions allow us to evaluate, plan and organize our actions to achieve a goal.

Full description

Some research shows that positive emotional states are associated with greater self-confidence, greater optimism, and better regulation of our decision-making. The goal is to test whether positive emotional induction could improve decision-making in Parkinson's disease.

Listening to music would decrease anxiety levels and increase self-esteem levels. Who says Parkinson says dopamine deficiency and so the investigators can think that the investigators can help patients by inducing a positive emotion through musical stimulation.

All participants will be subject to emotional induction. They will be divided into two different conditions: either they will be induced in a positive state, or they will be maintained in a neutral state. For this, video clips (positive or neutral) containing music will be presented. Immediately after the presentation of the video, participants will have to perform the Iowa Gambling Task test. This is a sequential task to evaluate decision-making capabilities.

Enrollment: 44 patients

Sex: All

Ages: 50 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria for patients :

• Diagnosis of the disease carried out by a hospital doctor
• Stable treatment for two months minimum.
• Mini-Mental Parkinson > 26
• Under dopaminergic treatment

Exclusion Criteria for patients :

• other neurological or psychiatric antecedents
• anxio-depressive symptomatology
• delusional or psychotic state

Inclusion Criteria for witnesses :

• matched in age and sex
• Vision and hearing normal or successfully corrected
• Understand the French language
• general level in the test standard

Exclusion Criteria for witnesses :

• neurological or psychiatric diseases
• anxio-depressive symptomatology

Trial design

Primary purpose: Other

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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44 participants in 2 patient groups

patients with Parkinson's disease

Other group

Description:

1. cognitive examination : mini mental test of Parkinson, Hospital Anxiety and Depression Scale, 5 words by Dubois, fast test frontal assessment, Trail Making Test 2. viewing of video : scale of differential emotions and Positive and Negative Affect Scale 3. Test of Iowa Gambling Task

Treatment:

Other: cognitive examination

Other: viewing of video

Other: Iowa Gambling Task

witnesses

Other group

Description:

1. cognitive examination : mini mental test of Parkinson, Hospital Anxiety and Depression Scale, 5 words by Dubois, fast test frontal assessment, Trail Making Test 2. viewing of video : scale of differential emotions and Positive and Negative Affect Scale 3. Test of Iowa Gambling Task

Treatment:

Other: cognitive examination

Other: viewing of video

Other: Iowa Gambling Task