Influence of Endurance Exercise and Histamine Receptors on the Gene Expression in Skeletal Muscle

University Ghent

Status: Completed

Conditions: Histamine; Exercise

Treatments: Drug: Placebo: Placebo + exercise training.; Drug: H1 blockade: H1 receptor antagonist + exercise training; Drug: H2 Blockade: H2 receptor antagonist + exercise training

Study type: Interventional

Funder types: Other

Identifiers

NCT05131555

AET - BC-10237

Details and patient eligibility

About

Blocking histamine H1/H2 receptors blunts chronic endurance training adaptations. The current study addresses a twofold research question: "What is the influence of endurance training (1) and histamine H1 and H2 signaling (2) on the gene expression in human skeletal muscle." Results from this study will yield more insights into the molecular mechanisms of adaptations to exercise training.

Enrollment: 14 patients

Sex: All

Ages: 18 to 45 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Male and female
• 18-45 years
• not to medium physically active

Exclusion criteria

• Smoking
• Chronic disease
• Supplement or medication intake
• Seasonal allergies

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Triple Blind

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14 participants in 3 patient groups, including a placebo group

1: Placebo

Placebo Comparator group

Description:

lactose

Treatment:

Drug: Placebo: Placebo + exercise training.

H1 blockade

Experimental group

Description:

540 mg Fexofenadine

Treatment:

Drug: H1 blockade: H1 receptor antagonist + exercise training

H2 blockade

Experimental group

Description:

40 mg Famotidine

Treatment:

Drug: H2 Blockade: H2 receptor antagonist + exercise training