Influence of Epidural Analgesia on Natural Killer Cell (NK) Activity After Colonic Cancer Surgery

Hillel Yaffe Medical Center

Status: Unknown

Conditions: Colonic Neoplasms

Treatments: Drug: Nitrous Oxide; Drug: Fentanyl; Drug: Ropivacaine; Drug: Propofol; Drug: Isoflurane

Study type: Interventional

Funder types: Other

Identifiers

NCT02326727

0095-14-HYMC

Details and patient eligibility

About

Regional anesthesia may decrease the release of endogenous opioids, increase Natural Killer cell (NK) function and decrease development of metastasis. The recent analysis of the Cancer Registry has noted an improved 5-year survival in patients who received epidural analgesia during surgery for colorectal carcinoma.

Enrollment: 30 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients undergoing colonic cancer surgery

Exclusion criteria

• Patients with poor physical status Patients needed emergency surgery Coagulopathic disorders with international normalized ratio (INR) level more than 1.4 Thrombocytopenia with platelets count less 100000 per mcl Allergic reaction to local anesthetics in patient history Failure to performing the epidural analgesia from another cause Preoperative immunomodulating treatment Recent history of chemotherapy or radiation therapy

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Single Group Assignment

Masking: Single Blind

---

30 participants in 2 patient groups

General Anesthesia

Active Comparator group

Description:

Patients receiving general anesthesia with Fentanyl,Propofol, Isoflurane and Nitrous Oxide only during colonic cancer surgery

Treatment:

Drug: Fentanyl

Drug: Propofol

Drug: Isoflurane

Drug: Nitrous Oxide

Combined anesthesia

Active Comparator group

Description:

Patients receiving general anesthesia and epidural analgesia with Ropivacaine during colonic cancer surgery

Treatment:

Drug: Fentanyl

Drug: Propofol

Drug: Ropivacaine

Drug: Isoflurane

Drug: Nitrous Oxide