Influence of Equilibration Rate Constant (ke0) of Propofol on the Effect Site Concentration for Loss of Consciousness

Seoul National University

Status: Completed

Conditions: General Anesthesia

Treatments: Device: Orchestra (Target-controlled infusion); Device: Diprifusor (Target-controlled infusion)

Study type: Interventional

Funder types: Other

Identifiers

NCT01091350

Orchestra vs Diprifusor

Details and patient eligibility

About

The aim of this study is to validate that an effect compartment concentration for loss of consciousness (LOC) was varied according to different Keo value.

Enrollment: 60 patients

Sex: Female

Ages: 20 to 60 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Adult patients undergoing general anesthesia

Exclusion criteria

• Hepatic or renal disease
• Drug addiction

Trial design

60 participants in 2 patient groups

Diprifusor group

Active Comparator group

Description:

Propofol was infused via Diprifusor TCI (Target-controlled infusion)

Treatment:

Device: Diprifusor (Target-controlled infusion)

Orchestra group

Experimental group

Description:

Propofol was infused via Orchestra TCI

Treatment:

Device: Orchestra (Target-controlled infusion)