Influence of G-CSF and EPO on Associative Learning and Motor Skills

University Hospital Muenster

Status and phase: Completed; Phase 2

Conditions: Amyotrophic Lateral Sclerosis; Chronic Stroke

Treatments: Drug: granulocyte - colony stimulating factor (G-CSF); Drug: erythropoetin (EPO)

Study type: Interventional

Funder types: Other

Identifiers

NCT00298597

EudraCT Number 2005-001113-18

GCSFEPO_01

Details and patient eligibility

About

In the study we want to prove whether the subcutaneous application of granulocyte-stimulating factor (G-CSF) and erythropoetin (EPO) influence associative learning and/or motor skills of patients, who suffer from chronic stroke or amyotrophic lateral sclerosis. The study hypothesis is that G-CSF and EPO improve associative learning and/or motor skills.

Enrollment: 180 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Diagnosis of chronic stroke or amyotrophic lateral sclerosis

Exclusion criteria

• leucocytes > 10000/µl
• hematocrit > 48%
• thrombocytes < 150000/µl
• severe rheumatoid arthritis
• severe infection
• severe liver or renal failure
• severe arterial hypertension
• recurrent thromboembolic events
• severe coronary heart disease
• myocardial infarction
• malignant tumor
• leukemia
• peripheral arterial occlusion disease

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind