Influence of Gender Specific Differences of Saliva Composition on the Development of Dental Erosion - an In-situ Study

University of Göttingen

Status

Completed

Conditions

Dental Erosion

Treatments

Other: Wearing of an intraoral device with bovine tooth samples

Study type

Observational

Funder types

Other

Identifiers

NCT02780973

7/10/15 (Other Identifier)

01681 (Other Identifier)

Erosion-Gender

Details and patient eligibility

About

Healthy volunteers are observationally wearing an intraoral device with bovine tooth samples once for two hours. Afterwards, Calcium release from the bovine enamel and dentin samples is measured after extraoral erosion.

Total protein concentration within the formed salivary pellicles on the bovine samples is determined. Further Salivary parameters (unstimulated and stimulated saliva flow rate, pH, buffer capacity, albumin and total protein content as well as concentration of inorganic calcium, phosphate and fluoride) are being measured.

The aim of this study is to investigate whether gender differences in the salivary composition correlate with predisposition to erosion.

Enrollment

50 patients

Sex

All

Ages

20 to 40 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Healthy probands aged between 20 and 40 years who are able to give written consent

Exclusion criteria

Non-fulfillment of the inclusion criteria
Smoking
Hyposalivation / xerostomia (unstimulated saliva < 0.3 mL/min, stimulated saliva < 0.7 mL/min)
Intake of any medication (except contraceptives in women)
Pregnant or lactating women
Known allergies to substances used in the study
Orthodontic treatment or malfunction which doesn't allow to wear an intraoral device