Influence of Heavy Metals Exposure on in Vitro Fertilization (IVF) Outcome

Rambam Health Care Campus

Status: Unknown

Conditions: Fertilization in Vitro

Study type: Observational

Funder types: Other

Identifiers

NCT02971280

0008-16-RMB

Details and patient eligibility

About

Exposure to heavy metals may interfere with basic cellular functions, including DNA synthesis.

The aim of the study is to correlate heavy metals concentration in body fluids of reproductive importance and IVF outcome.

Full description

Concentration of heavy metals will be measured in blood, urine, semen fluid and follicular fluid of IVF patients.

Study group: poor prognosis patients: repeated IVF failure, implantation failure, poor ovarian response, low sperm quality (according to WHO criteria) Control group: Good prognosis patients. Normal sperm count. Heavy metals concentrations will be measured using atomic absorption spectrometer, and will be correlated with IVF outcomes: number of mature oocytes obtained, fertilizations, embryos quality, and reproductive outcome post embryo transfer.

Enrollment: 100 estimated patients

Sex: All

Ages: 18 to 50 years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria

• Age of female patients: <=39
• Age of male patients: 18-50

Exclusion Criteria:

• Smoking
• Alcohol/drug abuse
• Long-term/chronic medications
• Severe health/mental problems
• Dental or other transplants
• Fragile X mutations
• Fertility preservation