Influence of Hesperidin and Vitamin C on Uric Acid Concentration (HesperiDrinC)

University of Kiel

Status: Completed

Conditions: Higher Uric Acid Concentrations (>5,5 mg/dl); Healthy

Treatments: Dietary Supplement: Vitamin C; Dietary Supplement: Hesperidin; Dietary Supplement: Control; Dietary Supplement: Hesperidin + Vitamin C

Study type: Interventional

Funder types: Other

Identifiers

NCT04316390

ABW-2020-OS2

Details and patient eligibility

About

Aim of the study is to investigate the impact of hesperidin and/or vitamin C on elevated uric acid concentrations.

Full description

Duration of the study is 9 weeks. 1) a washout week, 2) two intervention weeks, 3) four weeks washout period, 4) two intervention weeks.

The study is conducted under free living conditions. During washout weeks consumption of orange juice or citrus fruits or vitamin C containing supplements is restricted.

During intervention weeks 200 mL of study drink is consumed daily. And participants are asked to maintain their normal physical activity and habitual diet. Additional citrus or vitamin C containing beverages are not allowed.

At the beginning and the end of each intervention phase uric acid, insulin sensitivity, blood pressure, pulse wave velocity and bioavailability of hesperidin are assessed.

Enrollment: 40 patients

Sex: All

Ages: 20 to 80 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• healthy
• higher uric acid concentration (≥5.5 mg/dL)
• Informed written consent

Exclusion criteria

• pregnancy
• fructose intolerance
• smoking
• gout or medicated hyperuricemia
• diabetes mellitus
• antidiabetic or cytostatic medication
• weight loss (≥5% in the past 3 months)
• consumption of vitamin C-containing supplements
• parallel participation in a clinical trial
• anemia and / or iron deficiency

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Double Blind

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40 participants in 2 patient groups

Hesperidin (A)

Experimental group

Description:

study drink without hesperidin and without vitamin C compared to study drink with hesperidin

Treatment:

Dietary Supplement: Control

Dietary Supplement: Hesperidin

Hesperidin + Vitamin C (B)

Experimental group

Description:

study drink with vitamin C compared to study drink with hesperidin and vitamin C

Treatment:

Dietary Supplement: Vitamin C

Dietary Supplement: Hesperidin + Vitamin C