Influence of High Vitamin C Dose on Lactate During and After Extracorporeal Circulation

University Medical Centre Maribor

Status: Completed

Conditions: Hyperlactatemia; Bypass Complication; Cardiac Disease; Vitamin C; Valve Disease, Heart

Treatments: Other: Placebo (saline); Dietary Supplement: ascorbic acid,

Study type: Interventional

Funder types: Other

Identifiers

NCT04046861

UKC-MB-KME-20/19

Details and patient eligibility

About

The aim of our study is to find out whether high doses of vitamin C before cardiopulmonary bypass and during the first 24 hours after that have and impact of lowering the incidence of hyperlactatemia.

Enrollment: 70 patients

Sex: All

Ages: 18 to 100 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• > 18 years old patients with cardiac disease needing surgery (coronary bypass, valve replacement)

Exclusion criteria

• dementia
• kidney stones
• dialysis
• haemochromatosis
• thalassemias
• G-6-P deficiency

Trial design

Primary purpose: Supportive Care

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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70 participants in 2 patient groups, including a placebo group

Vitamin C

Active Comparator group

Description:

2g vitamin C (ascorbic acid) iv before cardiopulmonary bypass, 2 g vitamin C iv before removing the aortic clamp, 1g vitamin C iv 8 h after aortic clamp removal and every 8 h thereafter(2 times)

Treatment:

Dietary Supplement: ascorbic acid,

Placebo (saline)

Placebo Comparator group

Description:

placebo (saline) iv before cardiopulmonary bypass, placebo before removing the aortic clamp, placebo iv 8 h after aortic clamp removal and every 8 h (2 times)

Treatment:

Other: Placebo (saline)