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Influence of High Vitamin C Dose on Lactate During and After Extracorporeal Circulation

U

University Medical Centre Maribor

Status

Completed

Conditions

Hyperlactatemia
Bypass Complication
Cardiac Disease
Vitamin C
Valve Disease, Heart

Treatments

Other: Placebo (saline)
Dietary Supplement: ascorbic acid,

Study type

Interventional

Funder types

Other

Identifiers

NCT04046861
UKC-MB-KME-20/19

Details and patient eligibility

About

The aim of our study is to find out whether high doses of vitamin C before cardiopulmonary bypass and during the first 24 hours after that have and impact of lowering the incidence of hyperlactatemia.

Enrollment

70 patients

Sex

All

Ages

18 to 100 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • > 18 years old patients with cardiac disease needing surgery (coronary bypass, valve replacement)

Exclusion criteria

  • dementia
  • kidney stones
  • dialysis
  • haemochromatosis
  • thalassemias
  • G-6-P deficiency

Trial design

Primary purpose

Supportive Care

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

Triple Blind

70 participants in 2 patient groups, including a placebo group

Vitamin C
Active Comparator group
Description:
2g vitamin C (ascorbic acid) iv before cardiopulmonary bypass, 2 g vitamin C iv before removing the aortic clamp, 1g vitamin C iv 8 h after aortic clamp removal and every 8 h thereafter(2 times)
Treatment:
Dietary Supplement: ascorbic acid,
Placebo (saline)
Placebo Comparator group
Description:
placebo (saline) iv before cardiopulmonary bypass, placebo before removing the aortic clamp, placebo iv 8 h after aortic clamp removal and every 8 h (2 times)
Treatment:
Other: Placebo (saline)

Trial contacts and locations

1

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Central trial contact

Andreja Möller Petrun, PhD

Data sourced from clinicaltrials.gov

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