Influence of Injectable Platelet Rich Fibrin on Different Orthodontic Tooth Movements During Clear Aligner Therapy

Al-Azhar University

Status: Invitation-only

Conditions: Effect of Platelet Rich FibrinDuring Clear Aligner Therapy

Treatments: Biological: iPRF

Study type: Interventional

Funder types: Other

Identifiers

NCT06380946

978/91

Details and patient eligibility

About

The aim of this prospective clinical project will be to assess the effect of platelet rich fibrin on the rate of different orthodontic tooth movements during clear aligner therapy.

Full description

The aim of this prospective clinical project will be to assess the effect of platelet rich fibrin on the rate of different orthodontic tooth movements during clear aligner therapy.specifically canine retraction,incisors leveling and alignment,maxillary molar distalization and incisors intrusion

Enrollment: 78 estimated patients

Sex: All

Ages: 15 to 22 years old

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:A- leveling and alignment Eligibility criteria

1. Age ranges from 15 to 22 years. 2. Bilateral Class II molar relationship. 3. Skeletal Class I or mild Class II relationship. 4. Normal or decreased vertical height. 5. No posterior crowding or spaces. 6. Fully erupted maxillary first and second molars. 7. Congenitally missing or extracted third molars. 8. Good oral hygiene. 9. Absence of any periodontal disease and alveolar bone loss. 10. Absence of medications that may inhibit orthodontic movement

Lower incisor leveling and alignment Inclusion criteria Complete permanent dentition (third molars not included); Moderate mandibular anterior crowding (with little's irregularity index score greater than 4 mm) who required non-extraction approach in the mandibular arch; No tooth size, shape or root abnormalities visible on the patient's radiographic records; No spaces in the mandibular arch; No blocked out tooth that did not allow for placement of the bracket at the

initial bonding appointment; 6. No required management with interproximal stripping, inter-maxillary elastics, open NiTi springs, and removable or extra-oral devices. Canine retraction Eligibility criteria

Age, 15 to 25 years; Class ii division 1 malocclusion with mild or no crowding; No previous orthodontic treatment; No systemic disease that might have affected bone formation or density, such as osteoporosis, hyperparathyroidism, or vitamin d deficiency; Adequate oral hygiene; Probing depth values not exceeding 3 mm across the Entire dentition; Adequate thickness of the attached gingiva (1-2 mm); No radiographic evidence of bone loss

Exclusion Criteria:Patients who required surgery to correct skeletal discrepancies. Patients with congenital dentoskeletal disorders. Missed or mutilated teeth in maxillary arch. Patients with poor oral hygiene and/or periodontally compromised patients Severe dental crowding that necessitates an extraction approach 2. Abnormal anteroposterior and vertical relationships; 3. Patients with cleft lip and palate, anomalies, and syndromes; 4. Previous orthodontic 5. Treatment; 6. Regular medications intake that could interfere with otm. -

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Factorial Assignment

Masking: None (Open label)

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78 participants in 8 patient groups

Experimental:iPRF group closure of premolar extraction space

Experimental group

Description:

closure ofpremolar extraction space that will be performed with iPRFapplication according to a standardized protocol

Treatment:

Biological: iPRF

intervention group

No Intervention group

Description:

iPRFgroup closure of premolar extraction space control side

Experimental: iPRFgroup: distalization intervntion side

Experimental group

Description:

distalization will be commenced with application of iPRF according to a standardized protocol

Treatment:

Biological: iPRF

No Intervention: iPRF group: distalization control side

No Intervention group

Description:

distalization will be commenced without application of iPRF according to a standardized protocol

Experimental: iPRF group: leveling and alignment

Experimental group

Description:

leveling and alignment be commenced with application of iPRF according to a standardized protocol

Treatment:

Biological: iPRF

No Intervention: leveling and alignment without intervention

No Intervention group

Description:

leveling and alignment without intervention

Experimental: iPRF group: Intrusion

Experimental group

Description:

intrusion assisted with application of iPRF according to a standardized protocol

Treatment:

Biological: iPRF

No Intervention: intrusion control group

No Intervention group

Description:

intrusion without intervention