Influence of Intra-Canal Cryotherapy on Post-Endodontic Pain and Interleukin-6 Expression Using Different Irrigation Protocols: A Randomized Clinical Trial

Suez Canal University

Status: Completed

Conditions: Symptomatic Periapical Periodontitis

Treatments: Other: Cryotherapy

Study type: Interventional

Funder types: Other

Identifiers

NCT04324398

SuezCanalU

Details and patient eligibility

About

the study was to evaluate the effect of intra-canal cryotherapy on post-endodontic pain and interleukin-6 expression in teeth with symptomatic apical periodontitis using different irrigation protocols.

Enrollment: 48 patients

Sex: All

Ages: 20 to 50 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Anterior or premolar single canal in single rooted teeth.
• Patients aged 20 to 50 years.

Exclusion criteria

• Patients under anti-inflammatory medication, immune-suppressive chemotherapy or any antibiotic medication for the last 2 months.
• Pregnant or lactating females.
• Teeth with endo-perio lesions.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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48 participants in 4 patient groups

group I (control )

No Intervention group

Description:

irrigation with 5% sodium hypochlorite at room temperature from the beginning of cleaning and shaping, between each file and till the final rinse

Group II

Experimental group

Description:

irrigation with 5% cold sodium hypochlorite (2-5°C) from the beginning of cleaning and shaping and between each file. Final rinse was done by 20 mL of 5% cold sodium hypochlorite (2-5°C) for 5 minutes

Treatment:

Other: Cryotherapy

Group III

Experimental group

Description:

irrigation with 5% sodium hypochlorite at room temperature from the beginning of cleaning and shaping and between each file. Then final rinse with 20 mL of 5% cold sodium hypochlorite (2-5°C) for 5 minutes

Treatment:

Other: Cryotherapy

Group IV

Experimental group

Description:

irrigation with 5% sodium hypochlorite at room temperature from the beginning of cleaning and shaping and between each file. Then final rinse with 20 mL of cold saline (2-5°C) for 5 minutes

Treatment:

Other: Cryotherapy