Influence of Intracranial Lesions on Bispectral Index

University Medical Center Groningen (UMCG)

Status: Completed

Conditions: Supratentorial Brain Tumor

Treatments: Device: BIS values at return of consciousness in patients + predicted and measured propofol plasma concentrations

Study type: Observational

Funder types: Other

Identifiers

NCT01060631

BIS001

Details and patient eligibility

About

The purpose of this study is to assess whether BIS values at return of consciousness are different in patients with or without brain tumors.

Enrollment: 40 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients undergoing elective craniotomy for removal of frontal or frontotemporal brain tumors.
• Control group: Neurosurgical patients without intracranial pathology.

Exclusion criteria

• Patient refusal
• Significantly increased intracranial pressure
• Uncontrolled arterial hypertension
• Significant coronary artery disease
• Anticipated difficult airway
• Decreased level of consciousness
• Existing motor weakness dominant arm/hand
• Impaired hearing
• Nausea, vomiting

Trial design

40 participants in 2 patient groups

patients with frontal or frontotemporal brain tumor.

Treatment:

Device: BIS values at return of consciousness in patients + predicted and measured propofol plasma concentrations

Device: BIS values at return of consciousness in patients + predicted and measured propofol plasma concentrations

patients without supratentorial brain tumor.

Treatment:

Device: BIS values at return of consciousness in patients + predicted and measured propofol plasma concentrations

Device: BIS values at return of consciousness in patients + predicted and measured propofol plasma concentrations