Influence of Intrauterine Growth Restriction on Amplitude-integrated EEG in Preterm Infants

Medical University of Vienna

Status: Unknown

Conditions: EEG; Spikes, Centrotemporal, Epilepsy of Childhood; Premature - Weight 1000g-2499g or Gestation of 28-37weeks; Intrauterine Growth Restriction; Neurodevelopmental Disorder

Treatments: Other: aEEG

Study type: Observational

Funder types: Other

Identifiers

NCT01942525

KKS-07-2013

Details and patient eligibility

About

Objective: The impact of intrauterine growth restriction (IUGR) on perinatal morbidity and long-term neurodevelopmental outcome has been published in numerous studies. Throughout this analysis, the influence of IUGR on the postnatal amplitude-integrated EEG (aEEG) in preterm infants below 30 weeks of gestation was assessed. The second concern was the correlation between the pattern of the aEEG in the first two weeks with neurodevelopmental outcome, comparing infants with and without IUGR.

Methods: Routinely assessed aEEG data of preterm infants with IUGR born below 30 weeks of gestation in the years 2005 until 2007 were analysed retrospectively according to the aEEG score (combining occurrence of sleep-wake-cycles, background activity and suspected seizure activity). Neurodevelopmental outcome was evaluated at 24 months using the Bayley Scales of Infant Development and standardized neurologic examination.

Enrollment: 156 patients

Sex: All

Ages: 23 to 30 weeks old

Volunteers: No Healthy Volunteers

Inclusion criteria

• preterm infants below 30 weeks of gestation

Exclusion criteria

• congenital anomalies
• severe asphyxia

Trial design

156 participants in 2 patient groups

Intrauterine growth restriction

Description:

birth weight \<10th percentile first intervention: aEEG second intervention: assessment of neurodevelopmental follow-up

Treatment:

Other: aEEG

Appropriate for gestation age

Description:

control group with birth weight \>10th percentile first intervention: aEEG second intervention: assessment of neurodevelopmental follow-up

Treatment:

Other: aEEG