Influence of Losartan and Diphenhydramine on Emotional and Cognitive Functions in Healthy Human Subjects (LoDi-Basel)

Prof. Dominique de Quervain, MD

Status

Completed

Conditions

Memory, Long-Term

Memory, Short-Term

Treatments

Drug: Losartan, Diphenhydramine, Placebo

Study type

Interventional

Funder types

Other

Identifiers

NCT01321021

2011DR2032

Details and patient eligibility

About

This project aims at identifying novel pharmacological targets for the treatment of memory disorders.

Full description

To investigate the effects of the histamine H1 receptor antagonist diphenhydramine and the angiotensin II receptor antagonist losartan on emotional and cognitive functions in healthy human subjects.

Enrollment

80 patients

Sex

All

Ages

18 to 40 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

healthy
native or fluent German-speaking
BMI between 19 and 27 kg/m2
able and willing to give written informed consent and comply with the requirements of the study protocol
willing to donate saliva sample for DNA-analysis
female: willing to perform a pregnancy test at the beginning of both test visits

Exclusion criteria

acute or chronic psychiatric or somatic disorder
pathological ECG
known hypersensitivity to the IMP under investigation (losartan, diphenhydramine)
hypotension (RR < 110/70 mmHg)
bradycardia (< 50 bpm)
pregnancy, breast-feeding
long-term medication within last 3 months (oral contraceptives are disregarded)
smoking (> 3 cigarettes per day)
concurrent participation in another study
participation in one of our previous studies using the same memory tests
inability to read and understand the participant's information