Influence of Mango Intake of Skin Health in Postmenopausal Women (MSS)

University of California (UC) Davis

Status: Completed

Conditions: Skin Red; Wrinkle

Treatments: Other: 16 weeks mango intake

Study type: Interventional

Funder types: Other

Identifiers

NCT03590756

1185928

Details and patient eligibility

About

This study aims to investigate the effects on 16 weeks of mango intake on skin health in postmenopausal women. Half of the participants will receive 85g portions of mangoes while the other half receive 250g portions of mangos. Participants will be instructed to consume the specific portion 4 times a week, for a total duration of 16 weeks.

Full description

Mangoes are rich in carotenoids, flavonoids, vitamins and other active phytochemicals such as resistant starches. Although a role of mangoes in skin health has long been advocated in traditional medicine, little scientific research has been conducted.

We hypothesize that 85g (0.5 cups) of mango intake for 16 weeks will have minimal impact on skin health, while 250g (1.5 cups) of mango intake will produce significant benefits.

Enrollment: 36 patients

Sex: Female

Ages: 50 to 70 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Postmenopausal
• Fitzpatrick skin type I and II
• BMI 18.5 - 35.0 kg/m2
• Normal blood levels in the comprehensive metabolic panel, or values slightly out of range as approved by the study physician

Exclusion criteria

• Allergic to mangoes
• Fruit consumption of 2 or more cups per day
• Vegetable consumption of 3 or more cups per day for females
• Fruit juice consumption of more than 1 cup per day
• Self-reported malabsorption
• Currently taking regular prescription drugs i.e. statins, thyroid, anti-inflammatory drugs
• Had any medical or cosmetic procedures such as laser resurfacing or plastic surgery to the face within the last 6 months, including botulinum toxin, dermal fillers, collagen or other similar cosmetic procedure
• Autoimmune photosensitive condition or known genetic condition with a deficiency in collagen production (such as Ehler-Danlos)
• Smoking (current smoker, smoked within the past year, former smokers with greater than a 20 pack-year history of smoking within the past 20 years.
• Indications of substance or alcohol abuse
• Unwillingness to discontinue high antioxidant supplements during washout and interventions

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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36 participants in 2 patient groups

High mango group

Experimental group

Description:

250g (1.5 cup) of mango intake per day, 4 days a week for 16 weeks

Treatment:

Other: 16 weeks mango intake

Low mango group

Other group

Description:

85g (0.5 cup) of mango intake per day, 4 days a week for 16 weeks

Treatment:

Other: 16 weeks mango intake