Influence of Non Invasive Mechanical Ventilation on Tissue Perfusion in Patients After Cardiac Surgery

Federal University of São Paulo

Status: Completed

Conditions: Coronary Artery Disease; Heart Diseases

Treatments: Other: Noninvasive ventilation

Study type: Interventional

Funder types: Other

Identifiers

NCT02767687

1.156.460

Details and patient eligibility

About

This study evaluates whether noninvasive ventilation with continuous positive airway pressure affects tissue perfusion in patients after cardiac surgery.

Full description

Patients submitted to open chest cardiac surgery will be enrolled after ICU admission. These patients will be submitted to noninvasive mechanical ventilation with continuous positive airway pressure right after extubation and tissue perfusion markers (central venous oxygen saturation (SVcO2) and lactate) will be obtained via central venous catheter.

Noninvasive mechanical ventilation is a common resource in the ICU to reduce extubation failures and to improve clinical outcomes, whether it can influence tissue perfusion remains unclear.

This study evaluates whether noninvasive ventilation affects tissue perfusion and whether tissue perfusion markers in the ICU are correlated with better clinical results for patients after heart surgery.

Enrollment: 80 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Presence of central venous catheter
• Invasive arterial pressure catheter
• Invasive mechanical ventilation

Exclusion criteria

• Chronic obstructive pulmonary disease
• Morbid obesity
• Hemodynamic instability
• Spontaneous breathing
• Need of invasive mechanical ventilation for more than 24 hours
• Intolerance to noninvasive mechanical ventilation
• Extubation failure

Trial design

Primary purpose: Supportive Care

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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80 participants in 1 patient group

Noninvasive ventilation (NIV)

Experimental group

Description:

Noninvasive mechanical ventilation is a resource used to treat respiratory failure or to reestablish respiratory comfort and function. It is commonly used in the ICU with a regular mechanical ventilator and is offered using an interface that connects the machine to the patient. The interface used for adults and in this study, was a silicon facial mask that covers the nose and mouth of the patient, allowing him or her to open the eyes.

Treatment:

Other: Noninvasive ventilation