Influence of Non-steroidal Anti-inflammatory Drugs (NSAID) on Muscle Regeneration

Bispebjerg Hospital

Status: Completed

Conditions: Muscle Damage

Treatments: Drug: placebo; Drug: NSAID

Study type: Interventional

Funder types: Other

Identifiers

NCT00832663

AM_P64_BBH

H-D-2008-074

Details and patient eligibility

About

The purpose of this study is to determine the influence of non-steroidal anti-inflammatory drugs (NSAIDs) on muscle regeneration.

The investigators' hypothesis is that ingestion of NSAID will delay or impair muscle regeneration.

Full description

The model employed to induce muscle damage is electrical stimulation. Muscle biopsies will be examined to follow the response of satellite cells and muscle regeneration. Study participants will be randomly assigned to a placebo or NSAID group in a double-blinded manner.

Enrollment: 32 patients

Sex: Male

Ages: 18 to 35 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• male
• healthy
• does not exercise regularly

Exclusion criteria

• displays contraindications for taking NSAID
• well-trained

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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32 participants in 2 patient groups, including a placebo group

NSAID

Experimental group

Description:

receive NSAID

Treatment:

Drug: NSAID

Placebo

Placebo Comparator group

Description:

receive placebo

Treatment:

Drug: placebo