Influence of Nutritional and Inflammational Status on Survival of Hemodialysis Patients

Shamir Medical Center (Assaf-Harofeh)

Status: Unknown

Conditions: Inflammation; Body Composition

Study type: Observational

Funder types: Other

Identifiers

NCT00410137

43/06

Details and patient eligibility

About

prospective longitudinal measurements of nutritional status parameters (body composition by BIA, anthropometry and biochemical indexes), inflammatory response (CRP, inflammatory cytokines (IL-1, IL-6, IL-10),IGF-1, leptin and NOx blood levels) and morbidity and mortality data collection over 2 year period in patients receiving chronic hemodialysis.

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Male or female, age > 18 years, in chronic hemodialysis treatment at least 3 months
• Stable and adequate hemodialysis treatment three months prior to participation in study as defined by Kt/V > 1.2 and/or hemodialysis performed 4 hours 3 times weekly
• Patients with normal hydration status (edema-free), with no neuro-muscular diseases
• Informed consent obtained before any trial-related activities

Exclusion criteria

• Patients with edema, pleural effusion or ascites at their initial assessment

• Patients with active malignant disease or liver cirrhosis

• Patients with neuro-muscular diseases

• Patients on chronic treatment with steroids on doses > 10 mg/day Prednisone (or equivalent)

• Patients treated with immunosuppressive agents

• Patients suffering from

  • Acute vasculitis
  • Severe systemic infections
  • Heart failure (NYHA class III-IV)

• The receipt of any investigational drug within 1 month prior to initiating of this study