Influence of Paternal Age on Assisted Reproduction Outcome (MALE AGING)

Instituto Valenciano de Infertilidad, IVI VALENCIA

Status: Completed

Conditions: IUI Standard IVF/ICSI Cycles and Ovum Donation IVF/ICSI Cycles; We Will Retrospectively Assess Our Databases in Our Clinic; From January 2000 to December 2006; Who Were Referred to Our Unit to Cryopreserve Sperm During the Period; Instituto Valenciano de Infertilidad in Valencia (Spain); Searching for Assisted Reproduction Procedures

Study type: Observational

Funder types: Other

Identifiers

NCT00510861

VLC-MM-0205-507-26

Details and patient eligibility

About

In the recent years, there is an increasing tendency to the parenthood delay in developed countries, and there is not enough information available regarding the influence of the male's age on fertility. If any, the negative impact should be acting at advanced ages.

Our aim with this work was to determine the role of paternal age on IUI results embryo quality and IVF outcome. Evenmore, in order to standardize the female factor, good quality oocytes (from fertile oocyte donors) and only first IVF cycles in young women were considered.

Full description

A retrospective study has been designed with a total number of 2204 IUI, 1286 IVF cycles and 1412 IVF cycles with donated oocytes from 2000 to 2006.

The inclusion criteria will be for IUI: women under 38 years old, tubal patency demonstrated by hysterosalpingography, normal uterine scan, normal basal hormonal levels, body mass index < 27 kg/m2, and absence of polycystic ovarian syndrome and endometriosis. For normal IVF cycles and oocyte donation cycles only first cycles will be analyzed. Cycles will be studied only in couples with absence of severe male factor.

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• women under 38 years old, tubal patency demonstrated by hysterosalpingography, normal uterine scan, normal basal hormonal levels, body mass index < 27 kg/m2.

Exclusion criteria

• absence of polycystic ovarian syndrome, hydrosalpinx or endometriosis.
• Cycles were studied only in couples with absence of severe male factor.