Influence of Perioperative Fluid Balance on Serum Concentrations of Antibiotics and Surgical Site Infections

Johannes Gutenberg University (JGU)

Status: Completed

Conditions: Antibiotic; Anti-Bacterial Agents; Surgical Wound Infection

Treatments: Procedure: Blood sampling after antibiotic administration

Study type: Observational

Funder types: Other

Identifiers

NCT03408457

837.402.17 (11236)

U1111-1207-8265 (Registry Identifier)

Details and patient eligibility

About

This study evaluates antibiotic serum concentrations in correlation with perioperative fluid balance. Patients will be recruited in rectum and esophageal surgery (representative for low blood loss and restrictive fluid management) and in liver surgery (representative for high blood loss and liberal fluid management). The hypothesis is that high blood loss and liberal fluid management dilute antibiotic serum concentrations thereby potentially increasing surgical site infections.

Enrollment: 130 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• elective surgery of rectom, esophagus or liver with indication for a central venous catheter
• informed consent

Exclusion criteria

• pregnancy
• medical emergency
• participation in another study