Influence of Physical Exercise as Adjuvant Treatment in Patients With Alzheimer's Disease

European University Miguel de Cervantes

Status: Completed

Conditions: Alzheimer Disease

Treatments: Other: Supervised Physical Activity: Phase 1; Other: Supervised Physical Activity (AMRAP -As Many Repetitions As Possible): Phase 2

Study type: Interventional

Funder types: Other

Identifiers

NCT05862935

PI-DOC002-ALP

Details and patient eligibility

About

The goal of this non-randomized clinical trial is to assess the effects of strength training in the physical function of Alzheimer's disease (AD) patients. The main question it aims to answer are:

1. Is a basic strength training enough to improve physical function in AD patients?
2. Is an exercise intervention able to delayed the progression of the disease?
3. Is an AMRAP intervention feasible in AD patients?

Participants in the exercise group will perform a 16-weeks program divided in two phases (phase 1: basic strength training; phase 2: AMRAP training). Participants in both (exercise and control) groups will receive their usual care treatments which include occupational therapy, musicotherapy, cognitive stimulation and sensory stimulation.

Enrollment: 26 patients

Sex: All

Ages: 60+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• MMSE (Mini-Metal State Examination) score of ≥15 out of 35 (at screening less than 2 months prior to baseline visit)
• Age ≥60 years old
• Be able to walk with or without aids
• Be able to follow verbal instructions

Exclusion criteria

• Surgery in the last 3 months
• Exhibit clear signs of disorientation
• Clinically confirmed signs of aggressiveness

Trial design

Primary purpose: Treatment

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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26 participants in 2 patient groups

Supervised Physical Activity (Phase I: Strength training; Phase II: AMRAP training)

Experimental group

Description:

These patients, in addition to receiving the usual treatment for their pathology, carry out supervised activity consisting of: * Warm-up * Strength circuit; At phase I it will be a standard strength training, while at Phase 2 it will be an AMRAP training)

Treatment:

Other: Supervised Physical Activity: Phase 1

Other: Supervised Physical Activity (AMRAP -As Many Repetitions As Possible): Phase 2

Control

No Intervention group

Description:

These patients only receive the usual treatment for their pathology.