Influence of Plasma Rich in Growth Factors (PRGF) on Healing of Medial Collateral Ligament (MCL) Tear

Clalit Health Services

Status and phase: Withdrawn; Phase 3; Phase 2

Conditions: MCL Tear

Treatments: Biological: Plasma Rich in Growth Factors (PRGF); Drug: saline

Study type: Interventional

Funder types: Other

Identifiers

NCT00743886

5000

Details and patient eligibility

About

To evaluate the influence of Plasma Rich in Growth Factors (PRGF) on the healing process of medial collateral ligament (MCL) tear.

Full description

Autologous platelet-rich matrices may aid in the healing of ligaments & tendons by promoting and accelerating tissue healing because of the release of growth factors including transforming growth factor (TGF)-beta1 and platelet-derived growth factor (PDGF) from platelet alpha-granules.

Enrollment: 50 estimated patients

Sex: All

Ages: 18 to 40 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• age 18-40 years old
• diagnosed MCL tear grade 2/3

Exclusion criteria

• pregnancy
• mental or physical disabilities

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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50 participants in 2 patient groups, including a placebo group

2

Placebo Comparator group

Description:

saline

Treatment:

Drug: saline

1

Experimental group

Description:

Plasma Rich in Growth Factors (PRGF)

Treatment:

Biological: Plasma Rich in Growth Factors (PRGF)