Influence of Platelet Concentrates on Wound Healing

Hannover Medical School (MHH)

Status: Completed

Conditions: Platelet-Rich Plasma; Wound Healing Delayed

Treatments: Combination Product: Platelet-Rich Plasma

Study type: Interventional

Funder types: Other

Identifiers

NCT03667638

#1055-2011

Details and patient eligibility

About

Chronic soft tissues defects can extend into the fat layer or even deeper and can cause functional disadvantages. Split-thickness skin grafts (STSGs) used to cover these wounds have varying success rates. To improve wound healing in chronic wounds the authors have studied the application of autologous platelet concentrates in a human keratinocyte culture model in vitro and in a combination with surgical procedures in vivo as second line therapy in patients with initially failed wound closure.

Full description

For in vitro testing on keratinocytes a platelet-mediator concentrate (PMC) was processed with a commercially available bed-side system (ATR®, Curasan, Germany). In a clinical study soft tissue defects (n=5) were treated using a combination of surgical debridement and autologous platelet rich plasma (PRP). Time of healing as determined by epithelization as well as Laser Doppler Imaging to visualize blood flow were analyzed. Additionally, changes in "ease of surgical wound closure" were determined. Finally, the quality of life of patients was assessed using a validated questionnaire.

Enrollment: 5 patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• exposed tendons, ligaments or bone for >3 weeks
• no healing tendency

Exclusion criteria

• sepsis
• intensive care treatment
• continuous smoking
• pregnancy or breast feeding women
• participants of other studies.

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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5 participants in 1 patient group

PRP Intervention

Experimental group

Description:

PRP injection into wound border

Treatment:

Combination Product: Platelet-Rich Plasma