Influence of Platelet-Rich Fibrin on Post-extraction Alveolar Ridge Healing/Preservation as a Stand-alone or Adjunct to Particulate Graft

The University of Texas System (UT)

Status: Completed

Conditions: Extraction Socket Healing; Alveolar Ridge Preservation

Treatments: Procedure: Socket grafting with bone graft; Procedure: Socket grafting with PRF

Study type: Interventional

Funder types: Other

Identifiers

NCT02707536

HSC-DB-14-0190

Details and patient eligibility

About

The goal of this project is to evaluate the influence of platelet rich fibrin (PRF) in extraction socket healing with or without particulate bone graft. The hypothesis of this study is that PRF will enhance the extraction socket healing and new bone formation when compared to extraction sockets grafted without PRF.

Enrollment: 42 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Subjects ≥ 18 years of age
• Hopeless or non-restorable single non-molar tooth per quadrant with adjacent teeth present
• Maximum of two teeth can qualify per patient.
• The buccal plate must be ≥ 1mm in width with a 4-wall configuration.
• Cases requiring minimal sinus grafting (<3mm)
• Bone grafting limited to the apical portion of the osteotomy site

Exclusion criteria

• Exclusion Criteria:
• Untreated periodontal disease, endodontic-periodontal disease and/or caries
• The buccal plate must be ≤ 3mm in width with a 4-wall configuration.
• Patients with uncontrolled or severe systemic disease (Diabetes)
• Patients with medical conditions or taking medication associated with compromised bone healing (Diabetes, Autoimmune Dysfunction, Prolonged Cortisone Therapy, Chemotherapy, or Bisphosphonate Therapy)
• Current Smokers
• Subjects with extensive parafunctional habits (ie; bruxism)
• Subjects who demonstrate inadequate oral hygiene

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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42 participants in 4 patient groups

No socket grafting

No Intervention group

Description:

Extraction with normal socket healing

Socket grafting with platelet rich fibrin (PRF) alone

Active Comparator group

Description:

Extraction with socket grafting with platelet rich fibrin (PRF) alone.

Treatment:

Procedure: Socket grafting with PRF

Socket grafting with bone grafting alone

Active Comparator group

Description:

Extraction with socket grafting using bone graft (xenograft).

Treatment:

Procedure: Socket grafting with bone graft

Socket grafting with PRF and bone grafting

Active Comparator group

Description:

Extraction with socket grafting using PRF combined with bone graft (xenograft).

Treatment:

Procedure: Socket grafting with bone graft

Procedure: Socket grafting with PRF