Influence of Pneumonia on Delayed Cerebral Ischemia After Subarachnoid Hemorrhage . SAH-CIP (SubArrachnoid Hemorrhage - Cerebral Infarction Pneumonia)

Regional University Hospital Center (CHRU)

Status: Completed

Conditions: Subarachnoid Hemorrhage; Pneumonia, Bacterial

Study type: Observational

Funder types: Other

Identifiers

NCT05094349

SAH-CIP (29BRC19.0311)

Details and patient eligibility

About

Prognosis of subarachnoid hemorrhage (SAH) is scarce, indeed almost half patients die or become severely disable after SAH. Outcome is related to the severity of the initial bleeding and delayed cerebral infarction (DCI). Infection and more precisely pneumonia have been associated with poor outcome in SAH. However, the interaction between the two pathologic events remains unclear. Therefore, we hypothesized that DCI may be associated to pneumonia in SAH patients. Thus the aim of the study is to analyze the association between delayed cerebral infarction and pneumonia in patients with SAH.

Retrospective, observational, monocentric cohort study, including patient admitted in Neurosurgical Intensive Care Unit or Surgical Intensive Care Unit in the University Hospital of Brest (France) for non-traumatic SAH. Primary outcome is diagnosis of DCI on CT scan or MRI 3 months after SAH. Multivariate analysis is used to identify factors independently associated with DCI.

We plan to include between 200 and 250 patients in the analysis.

Enrollment: 224 patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• admitted in ICU in Brest University Hospital
• for non traumatic subarachnoid hemorrhage
• between july 2015 and december 2018

Exclusion criteria

• continuation of care out of Brest University Hospital after initial ICU stay
• refusal to participate