Influence of Polymorphisms in the ATP6V1 Gene of the V-ATPase on the Development of Incomplete Distal Renal Tubular Acidosis

I

Insel Gruppe AG, University Hospital Bern

Status

Completed

Conditions

Vacuolar Proton-Translocating ATPases
Acidosis, Renal Tubular
Nephrolithiasis

Treatments

Drug: Furosemide-Fludrocortisone-Test (test for urinary acidification)

Study type

Observational

Funder types

Other

Identifiers

NCT01690039
090/12

Details and patient eligibility

About

Purpose 1. To compare the performance of the two currently employed urinary acidifications tests in stone formers, the furosemide/fludrocortisone and ammonium chloride loading test. 2. To study the impact of polymorphisms in the genes ATP6V1B1, ATP6V0A4 and SLC4A1 on urinary acidification in stone formers.

Enrollment

170 patients

Sex

All

Ages

18+ years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • One or more episodes of nephrolithiasis

Exclusion criteria

  • Absence of informed consent
  • All conditions affecting renal acidification
  • Pregnancy
  • Nursing

Trial design

170 participants in 1 patient group

All study participants
Description:
Furosemide-Fludrocortisone-Test and Ammonium chloride-Loading Test will be performed in renal stone patients.
Treatment:
Drug: Furosemide-Fludrocortisone-Test (test for urinary acidification)

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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