Influence of Postoperative Cognitive Function in Patients With Sevoflurane Postconditioning on Carotid Intima Stripped

Zhejiang University

Status and phase: Unknown; Early Phase 1

Conditions: Carotid Artery Intima Stripped; Sevoflurane; Postoperative Cognitive Dysfunction

Treatments: Drug: Sevoflurane inhalant product

Study type: Interventional

Funder types: Other

Identifiers

NCT04950205

2021-0107

Details and patient eligibility

About

Brief summary: In order to get a better clinical plan for brain protection during perioperative anesthesia for high-risk patients - carotid intima stripped. We observing the hemodynamic changes of sevoflurane post-treatment in carotid intima stripped, the comparison of postoperative cognitive function and postoperative radiographic changes.

Enrollment: 140 estimated patients

Sex: All

Ages: 50 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• American Society of Anesthesiologists（ASA）：II-III
• Aged between 40 and 80 years
• Patients scheduled for surgery of Carotid stenosis under general anaesthesia

Exclusion criteria

• Has a history of mental illness can't cooperate,
• Serious heart block or cardiac decompensation or severe sinus slow (HR < 50 times/min),
• The abnormal nerve monitoring in operation, MMES preoperative score < 20 points,
• Any rescue unexpected occurred during the operation

Trial design

Primary purpose: Other

Allocation: Randomized

Interventional model: Single Group Assignment

Masking: Single Blind

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140 participants in 2 patient groups

Sevoflurane post conditioning group（S1）

Experimental group

Description:

propofol：0.05～0.1mg/(kg.min) maintain throughout the whole surgery ,1% sevoflurane plus after open Carotid artery until the end of surgery

Treatment:

Drug: Sevoflurane inhalant product

The control group（P）

No Intervention group

Description:

propofol：0.05～0.1mg/(kg.min) maintain throughout the whole surgery without sevoflurane