Influence of Preconceptional Obesity on the Myometrial Cells Differentiation Toward a Contractyl Phenotype (ObeDi)

University Hospital Center (CHU) Dijon Bourgogne

Status: Completed

Conditions: Pregnancy Complication

Treatments: Other: Myometrium biopsy and blood samples

Study type: Interventional

Funder types: Other

Identifiers

NCT01762683

LIRUSSI-AOI-2011

Details and patient eligibility

About

The purpose of this study is to improve the understanding of cellular mecanism involved in delivery disorders in obese women, first by characterizing the hyperplasia phenomenon of myometrail cells induced by inflammatory stimulation (Il-1B), then by studying the role of blood mononuclear cells, of leptine and of obese women sera to interfere with the transition of myometrial cells toward hyperplasia phenotype.

Enrollment: 38 patients

Sex: Female

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Informed consent signed
• Patient affiliated with a social security scheme
• In front of for obstetrical reasons to give birth by caesarean section (scheduled caesarean section)
• Or a woman who is not obese in labour and needs to undergo a cesarean section
• No obvious infectious context
• Age > 18 years old

Exclusion criteria

• Obvious inflammatory or autoimmune diseases
• Suspected or confirmed infectious context, including virale infection VIH, VHC, VHB
• Coagulation disorders

Trial design

Primary purpose: Basic Science

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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38 participants in 3 patient groups

pre-conceptional obesity with a scheduled cesarean section

Experimental group

Treatment:

Other: Myometrium biopsy and blood samples

non-obese women with a scheduled cesarean section

Active Comparator group

Treatment:

Other: Myometrium biopsy and blood samples

women entering labour

Active Comparator group

Description:

women entering labour for vaginal delivery and for vaginal delivery

Treatment:

Other: Myometrium biopsy and blood samples