Influence of Probiotic and Symbiotic in Body Weight, Blood Sugar and Lipemia of Obese Women

Universidade Federal do Rio de Janeiro

Status: Completed

Conditions: Obesity

Treatments: Dietary Supplement: Symbiotic; Dietary Supplement: Placebo; Dietary Supplement: Probiotic

Study type: Interventional

Funder types: Other

Identifiers

NCT02505854

CEP 104-14

Details and patient eligibility

About

The purpose of this study is to evaluate whether gut microbiota modulation by probiotic and symbiotic contribute with weight loss and improvement of metabolic parameters in women with obesity.

Full description

We will evaluate the effects of probiotic and symbiotic on weigh loss, blood glucose, lipid profile, metabolomic profile, and gut microbiota composition variables in women with obesity.

Enrollment: 32 patients

Sex: Female

Ages: 25 to 45 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Women;
• Adult;
• Obese (BMI between 30 and 39,9 Kg/m²).

Exclusion criteria

• Pregnancy or nursing;
• Smokers;
• Drinkers;
• Use of drug or phytotherapic;
• Diagnosis of any cronic disease;
• Daily consumption of yogurt.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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32 participants in 3 patient groups, including a placebo group

Probiotic

Active Comparator group

Description:

Hypocaloric diet associated with capsule containing 1billion UFC Bifidobacterium lactis and sache with 5 g of maltodextrin

Treatment:

Dietary Supplement: Probiotic

Symbiotic

Active Comparator group

Description:

Hypocaloric diet associated with capsule containing 1billion UFC Bifidobacterium lactis and sache with 5 g of fructooligosaccharide

Treatment:

Dietary Supplement: Symbiotic

Placebo

Placebo Comparator group

Description:

Hypocaloric diet associated with capsule containing 50g of gelatin and sache with 5 g of maltodextrin

Treatment:

Dietary Supplement: Placebo